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A mixture of (4-methoxyphenoxy) -1- (3- ((thien-2-ylmethyl) amino) -1H-pyrazol-1-yl) ethan-1-one and 2- (4-methoxyphenoxy) -1- (5- ((thien-2-ylmethyl) amino) -1H-pyrazol-1-yl) ethanone (19.5g, 56.8mmol) was dissolved in a small amount of anhydrous DCM to help transfer it to a 500mL round bottom flask

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An RDP study with 155 peri-menopausal women found the menopause symptoms assessed by the Womens Health Questionnaire (WHQ) to be significantly improved after six month of Pycnogenol supplementation, as compared to placebo controls (12)

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